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. 2017 Sep 8;10:4379–4391. doi: 10.2147/OTT.S143518

Figure 7.

Figure 7

DEPTOR knockdown inhibits the progression of OS by regulating the PI3K/AKT/mTOR pathway.

Note: After 48 h of transfection, the expression levels of PI3K/AKT/mTOR pathway-related proteins, PI3K, AKT, p-AKT, mTOR, p-mTOR, 4E-BP1, and p-4E-BP1, were determined by Western blot.

Abbreviations: DEPTOR, DEP-domain containing mTOR-interacting protein; mTOR, mammalian target of rapamycin; OS, osteosarcoma.