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. Author manuscript; available in PMC: 2018 Apr 18.
Published in final edited form as: Chem Soc Rev. 2017 Apr 18;46(8):2038–2056. doi: 10.1039/c6cs00803h

Figure 10.

Figure 10

(a) Construction of immuno-magnetosomes (IMSs) and the procedure of CTC enrichment. The magnetic nanoclusters (MNCs) were camouflaged with leukocyte membrane fragments (LMNC) through electrostatic interaction. The leukocyte membrane is pre-engineered with azide (N3) via intrinsic biosynthesis and the metabolic incorporation of phospholipids to construct N3-LMNCs. The Ab is conjugated on the surface of N3-LMNCs through mild and highly efficient click chemistry. (b,c) CLSM images of N3-LMNCs (b) and IMSs (c) after reaction with fluorescent secondary antibody, demonstrating the success of DBCO-Abs conjugation to N3-LMNCs. Reproduced from reference 18 with permission from Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, copyright 2016.