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. Author manuscript; available in PMC: 2018 Apr 18.
Published in final edited form as: Chem Soc Rev. 2017 Apr 18;46(8):2038–2056. doi: 10.1039/c6cs00803h

Figure 6.

Figure 6

Intrinsic nanotopological sensing for capturing cancer cells. (a, b) Schematic of nanotopography generated by RIE on glass surfaces. Insets show a zoom-in (left) and SEM (right) images of cancer cells captured on nanorough glass surfaces. (c) SEM images of glass surfaces with their RMS nanoroughness indicated. (d-g) Cancer cells spiked in growth media at a concentration of 105 mL-1 captured on glass surfaces 1 h after cell seeding. Fluorescence images of MCF-7 cells (stained for nuclei, DAPI, green) captured on glass surfaces coated with (bottom) or without (top) EpCAM antibodies (d). Capture yields of MCF-7 (e), MDA-MB-231 (f), and other cancer cell lines (g) as a function of nanoroughness. Reproduced from reference 36 with permission from American Chemical Society, copyright 2013.