Table 1. Best results of recovery rate, purity and/or LOD of the current CTC detection technologies.
| CTC Detection Technologies a | Without Enrichment | Negative Enrichment | In vivo Enrichment | Without Ligand Capture | With Ligand Capture-Single Modality Enrichment | With Ligand Capture-Dual Modality Enrichment |
|---|---|---|---|---|---|---|
| Recovery Rate (%) b | - | ∼ 90 | ∼33 | 97 | 95 | >99 |
| Purity (%) c | - | 3.64 | - | < 10 | 84 | >92 |
| LOD (cells / mL) d | 1 | 1 | 0.12 | 2.2 | 1 | - |
| Refs | 23, 27 | 29, 30 | 32 | 35, 37 | 18, 19, 41 | 50 |
a
The currently reported CTC detection technologies as classified in Scheme 1.
b
The number percentage of the enriched CTCs to the total CTCs in the blood, which is also named as capture efficiency or enrichment efficiency in some literatures.
c
The number percentage of the enriched CTCs to the total cells in the enriched samples.
d
The limit of the CTC concentration in the blood that could be detected.