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. 2017 Aug 24;10(9):673–687. doi: 10.1177/1756283X17726018

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© The Author(s), 2017

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — Clinical trial design. Dosing numbers were targets and do not reflect the number of patients recruited for each treatment arm. BID, twice daily; TID, three times daily.

*Day 1 may occur on same day as qualification visit or 3 to 5 days after, if assigned study drug is not onsite.