Table 4.

Results from the random effects meta-regression model considering the different patient and study-level variables.

	N	Level	β-coefficient	Standard error (β)	t	P value	τ 2a	Adj. R2 (%)b
Endpoint myocardial infarction
Covariates
None	16		0.4296	0.1133	3.79	0.002	0.1395	−
Coronary heart disease at baseline	16	yes/no	−0.5870	0.1847	−3.18	0.007	0.0598	57.15
Composite endpoint	16	yes/no	0.4183	0.3063	1.37	0.194	0.1353	3.02
Mean age of the cohort	16	years	−0.0245	0.0140	−1.75	0.103	0.1162	16.71
Male gender of the cohort	16	percentage	−0.0078	0.0037	−2.12	0.053	0.1031	26.08
Prospective cohort study	16	yes/no	0.4027	0.2164	1.86	0.084	0.1236	11.42
Publication year of studies	16	year	0.0313	0.0356	0.88	0.394	0.1373	1.56
Endpoint all-cause mortality
Covariates
None	13		0.6601	0.1107	5.96	<0.001	0.1301	−
Coronary heart disease at baseline	13	yes/no	0.2188	0.2268	0.96	0.356	0.1270	2.38
Mean age of the cohort	13	years	0.0033	0.0192	0.17	0.866	0.1418	−8.95
Male gender of the cohort	13	percentage	0.0006	0.0039	0.14	0.889	0.1448	−11.28
Prospective cohort study	13	yes/no	0.4371	0.2072	2.11	0.059	0.0970	25.48
Publication year of studies	13	year	−0.0253	0.0364	−0.70	0.501	0.1352	−3.89
Endpoint heart failure
Covariates
None	9		1.5302	0.2024	7.56	<0.001	0.3349	−
Coronary heart disease at baseline	9	yes/no	−0.7321	0.3648	−2.01	0.085	0.2335	30.28
Mean age of the cohort	9	years	−0.0338	0.0321	−1.05	0.328	0.3218	3.92
Male gender of the cohort	9	percentage	−0.0102	0.0052	−1.94	0.093	0.2436	27.27
Prospective cohort study	9	yes/no	0.8720	0.4398	1.98	0.088	0.2136	36.24
Publication year of studies	9	year	0.0517	0.0628	0.82	0.438	0.3490	−4.19

^aτ², between-study variance.

^bProportion of between-study variance (heterogeneity) explained by the covariate.