Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Sep 15;45(10):e1075–e1082. doi: 10.1097/CCM.0000000000002646

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine and Wolters Kluwer Health, Inc.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

PMC Copyright notice

Figure 1. — Selectively activating basal forebrain cholinergic neurons attenuated the systemic inflammatory response to cecal ligation and puncture (CLP)–induced sepsis. After photostimulation of basal forebrain cholinergic neurons and CLP surgery, blood was collected at 3 and 12 hr (n = 6–10 per group). A, The model of experiment protocol. B, Schematic drawing shows the detailed methods of photostimulation and CLP. C–D, The pro-inflammatory cytokines tumor necrosis factor (TNF)-α and interleukin (IL)-6 were present at lower levels in photostimulated ChAT septic mice. E, There was no significant difference in the levels of anti-inflammatory cytokines (IL-10) between ChAT-lit septic mice and ChAT-unlit septic mice. These data are presented as the mean ± sem (*p < 0.05, **p < 0.01, ***p < 0.001). NS = no significant difference, WT = wild type.