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. 2017 Sep 15;45(10):e1075–e1082. doi: 10.1097/CCM.0000000000002646

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Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine and Wolters Kluwer Health, Inc.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 2. — In cecal ligation and puncture (CLP)–induced sepsis, splenic inflammatory cytokines were regulated by the photostimulation of basal forebrain cholinergic neurons. Wild-type (WT) and ChAT mice were treated with photostimulation. Spleens were then collected at 3 and 12 hr after CLP (n = 6–10 per group). A–B, The levels of tumor necrosis factor (TNF)-α and interleukin (IL)-6 were significantly lower in the spleens of photostimulated ChAT mice after CLP. C, The levels of IL-10 were not different between the spleens of ChAT mice that were treated or not treated with photostimulation after CLP. The data are presented as the mean ± sem (*p < 0.05, **p < 0.01, ***p < 0.001). NS = no significant difference.