Table 3. Summary of expression changes of significantly up-regulated and down-regulated genes at different hours post injection (hpi) following immune stimulation by β glucan, Poly I:C and R848 in liver, kidney and spleen of rag1-/- mutant fish.
| Treatment | Tissues | <10 fold change | 10–100 fold change | >100 fold change | Down regulated genes |
|---|---|---|---|---|---|
| β glucan | Liver | tnfα (1 hpi) | ifnγ (1 hpi) | ||
| tnfα (12 hpi) | ifnγ (6 hpi) | ||||
| ifnγ (12 hpi) | |||||
| ifnγ (24 hpi) | |||||
| Kidney | tnfα (1 hpi) | ifnγ (1 hpi) | ifnγ (6 hpi) | ||
| tnfα (6 hpi) | ifnγ (12 hpi) | ||||
| t-bet (6 hpi) | |||||
| Spleen | ifnγ (1 hpi) | ifnγ (6 hpi) | |||
| ifnγ (12 hpi) | ifnγ (24 hpi) | ||||
| Poly I:C | Liver | mx (1 hpi) | |||
| mx (6 hpi) | |||||
| mx (12 hpi) | |||||
| mx (24 hpi) | |||||
| Kidney | ifnγ (12 hpi) | mx (6 hpi) | tnfα (24 hpi) | ||
| t-bet (6 hpi) | mx (12 hpi) | ||||
| mx (24 hpi) | |||||
| nitr9 (1 hpi) | |||||
| Spleen | mx (6 hpi) | mx (12 hpi) | tnfα (24 hpi) | ||
| R848 | Liver | nitr9 (6 hpi) | ifnγ (12 hpi) | ifnγ (6 hpi) | |
| ifnγ (24 hpi) | t-bet (1 hpi) | ||||
| nitr9 (1 hpi) | t-bet (24 hpi) | ||||
| t-bet (6 hpi) | |||||
| mx (1 hpi) | |||||
| mx (6 hpi) | |||||
| mx (12 hpi) | |||||
| mx (24 hpi) | |||||
| Kidney | t-bet (1 hpi) | ifnγ (1 hpi) | ifnγ (6 hpi) | ||
| t-bet (6 hpi) | ifnγ (12 hpi) | ||||
| ifnγ (24 hpi) | |||||
| nitr9 (6 hpi) | |||||
| mx (1 hpi) | |||||
| mx (6 hpi) | |||||
| mx (12 hpi) | |||||
| mx (24 hpi) | |||||
| Spleen | mx (6 hpi) | ||||
| mx (12 hpi) | |||||
| ifnγ (6 hpi) | |||||
| ifnγ (12 hpi) | |||||
| ifnγ (24 hpi) |
Level of expression is relative to time zero samples.