Table 2. Regions of ReHo deficits in patients with MDD or EOD or LOD compared with HC.
| Brain region | Side | Cluster size(Voxels) | MNI Coordinates (mm) | Z-Score | p value | ||
|---|---|---|---|---|---|---|---|
| x | y | z | |||||
| EOD<young HC | |||||||
| NA | |||||||
| EOD>young HC | |||||||
| Middle frontal gyrus extend to postcentral gyrus | R | 262 | 27 | -39 | 39 | 5.0518 | <0.05 |
| Calcarine | R | 532 | 21 | -48 | 6 | 5.479 | <0.05 |
| LOD<old HC | |||||||
| Inferior occipital gyrus | L | 263 | -30 | -96 | -6 | -4.95 | <0.05 |
| Calcarine | L | 594 | -15 | -54 | 6 | -5.5784 | <0.05 |
| Middle occipital gyrus | R | 100 | 51 | -78 | 6 | -4.7043 | <0.05 |
| Supplementary motor area | L | 381 | -9 | 0 | 78 | -5.4324 | <0.05 |
| LOD>old HC | |||||||
| Middle frontal gyrus extend to postcentral gyrus | R | 1063 | 39 | -27 | 36 | 5.1626 | <0.05 |
| Hippocampus | L | 127 | -30 | -30 | -6 | 4.7932 | <0.05 |
| Insula | R | 213 | 45 | 6 | -3 | 4.3938 | <0.05 |
| EOD<LOD | |||||||
| Fusiform | R | 121 | 45 | -21 | -18 | -3.4599 | <0.05* |
| EOD>LOD | |||||||
| Precuneus | L | 318 | -12 | -66 | 60 | 3.3342 | <0.05* |
x,y,z are the coordinates of primary peak locations in the MNI space; Z is the statistical value of peak voxel showing ReHo differences among the EOD, LOD subgroups and healthy subjects. P<0.05, FDR corrected, cluster size≥100
* P<0.05, uncorrected, cluster size≥100.
EOD = early adult onset depression; LOD = later adult onset depression; HC = healthy controls.