Fig 3. Elevated circulating levels of cathelicidin and HBD2 in bilateral and cavitary disease in PTB individuals and relationship to bacterial burdens.

(A) The plasma levels of cathelicidin (LL37), HBD2, HNP1-3 and granulysin were measured in PTB individuals with bilateral vs unilateral disease. (B) The plasma levels of cathelicidin (LL37), HBD2, HNP1-3 and granulysin were measured in PTB individuals with cavitary vs non-cavitary disease. (C) The relationship between the plasma levels of cathelicidin (LL37), HBD2, HNP1-3 and granulysin and smear grades as estimated by sputum smears was examined in PTB individuals. The data are presented as scatter plots with each circle representing a single individual. P values were calculated using the Mann-Whitney test or the Linear trend post—test.