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. 2017 Jul 24;6(9):e1338230. doi: 10.1080/2162402X.2017.1338230

Figure 5.

Figure 5.

Combination immunotherapy targeting HPV E6 and E7 induces accumulation of CD103+ cells in vivo. A) Schematic depiction of the TC1 mouse model. B) Representative flow cytometric plot of a TC1 tumor digest analyzed for expression of CD103 and CD8 within the DAPI-negative live cell population. C) Representative flow cytometric plots of TC1 tumor digests from untreated mice or mice treated with irradiation, a low dose of SFV E6/E7 vaccine, or both analyzed for expression of CD8 and CD103 within the DAPI-negative live cell population. D) Bar graphs representing the absolute number of CD103+ cells per gram of tumor of the experimental groups (n = 3–6). E) Scatter plots representing the number of CD103+ cells per gram of tumor across all groups (n = 3–6). F) Percentage of E7-specific CD8+ T cells across all treatment groups. *p < 0.05.