Table 1.
KD values measured for the interactions between indicated form of Elo and human recombinant forms of the extracellular domain of CD16 (low affinity 158V or higher affinity 158F alleles), CD32a (low affinity 131R or higher affinity 131H alleles), CD32b, and CD64.
| KD, μM |
|||
|---|---|---|---|
| Elo | Elo n/f | Elo Fc mut | |
| CD16–158F | 2–5 | ≈0.1 | >>100 |
| CD16–158V | 0.36 ± 0.04 | ≈0.014 | >100 |
| CD32a-131H | 1.3 ± 0.1 | 1.6 ± 0.2 | >>200 |
| CD32a-131R | 1.4 ± 0.1 | 0.88 ± 0.08 | ≥10 |
| CD32b | ≥ 10 | ≥ 10 | >>10 |
| CD64 | 0.000073 ± 0.00001 | 0.000047 ± 0.00001 | >10 |