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. Author manuscript; available in PMC: 2017 Nov 23.
Published in final edited form as: J Am Chem Soc. 2017 Aug 10;139(33):11337–11340. doi: 10.1021/jacs.7b06555

Figure 4.

Figure 4

The reversibility of H3K27 acetylation and IL1RN expression. Enrichments of FLAG-ABI-P300 at primer 5 locus (a) and H3K27Ac at primer 1 locus (b) at the IL1RN locus at indicated time points after ABA treatment with or without washing. (c) Reversing rate of H3K27Ac at the IL1RN locus after ABA removal. (d) Levels of IL1RN mRNA at indicated time points after ABA treatment, or after washing. ### represents P<0.001 compared with 48 h; *** represents P<0.001 compared with 24 h; ˆˆˆ represents P<0.001 compared with 12 h. Fold enrichments were calculated by comparing to DMSO controls. Error bars represent ± s.e.m. from biological replicates (n = 6; a, b or n = 8; c).