Figure 3. Clonality of UCS tumors compared with other TCGA tumor types.

(A) Sorted mutation counts for each tumor separated by tumor type. All mutations are plotted in blue, clonal mutations in red, mutations in Significantly Mutated Genes (SMG) are light blue and clonal SMG mutations in magenta. All data was uniformly processed through the ABSOLUTE pipeline that includes adjustment for cellularity. SMGs for other tumor types were based on www.tumorportal.org (Lawrence et al., 2014). Labels across the top of the plot indicate the count of tumors included for each tumor type. (B) Boxplots showing the clonal proportion of mutations. Boxplot center lines (red) represent tumor medians, box limits (blue) are the inter-quartile range from 25% and 75%, whiskers (black) represent the extent of tumors out to 1.5 times the inter-quartile range, and red crosses are outliers beyond 1.5 times the inter-quartile range. (C) Boxplots showing the clonal proportion of SMGs. Components of the figure are as defined in panel (B). BLCA, bladder urothelial carcinoma; BRCA, breast invasive carcinoma; GBM, glioblastoma; KICH, kidney chromophobe; KIRC, kidney renal clear cell carcinoma; KIRP, kidney renal papillary cell carcinoma; LGG, low grade glioma; LUAD, lung adenocarcinoma; LUSC, lung squamous cell carcinoma; SKCM, skin cutaneous melanoma; STAD, stomach adenocarcinoma; THCA thyroid carcinoma; UCEC, uterine corpus endometrial carcinoma; UCS, uterine carcinosarcoma.