Table 2.
Baseline distribution of semi-quantitative MRI-based markers: Odds ratios (95% confidence intervals) from logistic regression models for baseline markers predicting case status (radiographic and pain progression).
| Domain | Category | Control | Case (radiographic and pain progression) |
OR* (95% CI) |
|---|---|---|---|---|
| CART | Cartilage morphology: max thickness score across entire knee | |||
| 0 | 118 (29.1%) | 32 (16.5%) | REF | |
| 1 | 83 (20.4%) | 44 (22.7%) | 2.1 (1.2, 3.6) | |
| 2 | 184 (45.3%) | 106 (54.6%) | 2.2 (1.4, 3.6) | |
| 3 | 21 (5.2%) | 12 (6.2%) | 2.1 (0.9, 4.9) | |
| Cartilage morphology: number of subregions with thickness score>0 across entire knee | ||||
| 0 | 118 (29.1%) | 32 (16.5%) | REF | |
| 1–2 | 194 (47.8%) | 98 (50.5%) | 2.0 (1.2, 3.2) | |
| 3+ | 94 (23.2%) | 64 (33.0%) | 2.6 (1.5, 4.4) | |
| Cartilage morphology: max surface area score across entire knee | ||||
| 0–1 | 34 (8.4%) | 6 (3.1%) | REF | |
| 2 | 297 (73.2%) | 133 (68.6%) | 2.6 (1.0, 6.5) | |
| 3 | 75 (18.5%) | 55 (28.4%) | 4.2 (1.6, 11.2) | |
| Cartilage morphology: number of subregions with surface area score>0 across entire knee | ||||
| 0–1 | 40 (9.9%) | 5 (2.6%) | REF | |
| 2–4 | 174 (42.9%) | 56 (28.9%) | 2.9 (1.0, 7.8) | |
| 5–7 | 153 (37.7%) | 96 (49.5%) | 6.4 (2.3, 18.0) | |
| 8+ | 39 (9.6%) | 37 (19.1%) | 10.3 (3.3, 31.8) | |
|
| ||||
| OST | Number of locations affected by any osteophyte | |||
| 0–2 | 81 (20.0%) | 14 (7.2%) | REF | |
| 3–5 | 120 (29.6%) | 39 (20.1%) | 1.8 (0.9, 3.6) | |
| 6+ | 205 (50.5%) | 141 (72.7%) | 4.4 (2.3, 8.5) | |
| Max osteophyte score in knee | ||||
| 0–1 | 224 (55.2%) | 85 (43.8%) | REF | |
| 2 | 132 (32.5%) | 70 (36.1%) | 1.4 (0.9, 2.2) | |
| 3 | 50 (12.3%) | 39 (20.1%) | 2.1 (1.2, 3.6) | |
|
| ||||
| MEN | Meniscal morphology: max grade across all locations | |||
| 0 | 178 (43.8%) | 75 (38.7%) | REF | |
| 1 | 114 (28.1%) | 65 (33.5%) | 1.3 (0.9, 2.1) | |
| 2 | 114 (28.1%) | 54 (27.8%) | 0.8 (0.5, 1.5) | |
| Medial meniscal extrusion - medially | ||||
| Grade 0: < 2mm extrusion | 151 (37.4%) | 51 (26.3%) | REF | |
| Grade 1: 2–2.9mm extrusion | 119 (29.5%) | 57 (29.4%) | 1.5 (0.9, 2.4) | |
| Grade 2: 3–4.9mm extrusion | 106 (26.2%) | 58 (29.9%) | 1.8 (1.1, 3.1) | |
| Grade 3: > 5mm extrusion | 28 (6.9%) | 28 (14.4%) | 3.3 (1.6, 6.8) | |
|
| ||||
| BML | Number of subregions affected by any BML | |||
| 0 | 55 (13.5%) | 11 (5.7%) | REF | |
| 1 | 76 (18.7%) | 22 (11.3%) | 1.4 (0.6, 3.3) | |
| 2 | 88 (21.7%) | 38 (19.6%) | 2.3 (1.1, 5.1) | |
| 3 | 88 (21.7%) | 41 (21.1%) | 2.5 (1.2, 5.5) | |
| 4 | 52 (12.8%) | 32 (16.5%) | 3.3 (1.5, 7.4) | |
| 5+ | 47 (11.6%) | 50 (25.8%) | 6.1 (2.7, 13.7) | |
| Max BML score in knee | ||||
| 0 | 55 (13.5%) | 11 (5.7%) | REF | |
| 1 | 148 (36.5%) | 75 (38.7%) | 2.4 (1.2, 5.0) | |
| 2 | 138 (34.0%) | 64 (33.0%) | 2.2 (1.1, 4.6) | |
| 3 | 65 (16.0%) | 44 (22.7%) | 3.5 (1.6, 7.7) | |
|
| ||||
| SYN | Hoffa-Synovitis | |||
| 0 | 186 (45.8%) | 60 (30.9%) | REF | |
| 1 | 190 (46.8%) | 112 (57.7%) | 1.8 (1.3, 2.7) | |
| 2–3 | 30 (7.4%) | 22 (11.3%) | 2.2 (1.2, 4.3) | |
|
| ||||
| EFF | Synovitis-Effusion | |||
| 0–1 | 332 (81.8%) | 151 (77.8%) | REF | |
| 2–3 | 74 (18.2%) | 43 (22.2%) | 1.3 (0.8, 2.0) | |
*
Univariate models for each marker adjusted for sex, race, and baseline age, BMI, KLG, WOMAC pain, pain medication and min JSW.