Table 3.

Effect of nanoparticle dosage platform on pharmacokinetic parameters of ETR using noncompartmental analysis.

Biological sample	t_1/2z (h)^a		T_max (h)	C_max (μg/g)^b		AUC_0-72h (hr•μg/g)^c		AUC_fib/ AUC_sus	AUC_0-∞ (hr•μg/g)^c		AUC_fib/AUC_sus

	Mean (±SEM)	P		Mean (±SEM)	P	Mean (±SEM)	P		Mean (±SEM)	P
*Plasma*
Suspension	8.11 (1.39)	0.1576	1.35	0.0038 (0.0006)	0.0170	0.024 (0.003)	0.0008	1.79	0.024 (0.003)	0.0215	2.58
Fibers	55.98 (30.67)	0.1576	1.35	0.0019 (0.0002)	0.0170	0.043 (0.002)	0.0008	1.79	0.062 (0.013)	0.0215	2.58
*Vaginal lavage*
Suspension	36.41 (18.77)	0.6054	1.35	9.72 (1.96)	<0.0001	194.94 (29.54)	<0.0001	12.82	287.33 (118.81)	0.0040	15.40
Fibers	54.53 (27.99)	0.6054	1.35	47.51 (0.94)	<0.0001	2,498.98 (85.08)	<0.0001	12.82	4,423.60 (1,028.66)	0.0040	15.40
*Vagina*
Suspension	35.36 (14.92)	0.9245	1.35	4.66 (0.35)	0.0002	44.29 (5.69)	0.1582	1.23	50.13 (5.96)	0.0555	1.38
Fibers	33.17 (16.71)	0.9245	1.35	1.93 (0.24)	0.0002	54.26 (2.94)	0.1582	1.23	69.13 (6.04)	0.0555	1.38
*Liver*
Suspension	17.17 (4.69)	0.2592	1.35	0.028 (0.005)	0.1247	0.266 (0.028)	0.0007	1.81	0.278 (0.031)	0.0020	2.59
Fibers	42.13 (20.01)	0.2592	6.47	0.018 (0.003)	0.1247	0.481 (0.029)	0.0007	1.81	0.721 (0.093)	0.0020	2.59
*Rectum*
Suspension	75.41 (68.69)	0.5190	1.35	0.049 (0.020)	0.5213	0.63 (0.11)	0.0253	2.27	1.32 (0.79)	0.3774	1.61
Fibers	28.82 (7.26)	0.5190	24.38	0.033 (0.013)	0.5213	1.43 (0.27)	0.0253	2.27	2.12 (0.33)	0.3774	1.61
*Uterine horn*
Suspension	NA	NA	1.35	0.041 (0.015)	>0.9999	0.65 (0.11)	0.0261	2.03	1.73 (4.23)	0.9490	1.16
Fibers	26.83 (9.59)	NA	12.52	0.041 (0.017)	>0.9999	1.32 (0.22)	0.0261	2.03	2.01 (0.36)	0.9490	1.16

Used data from 0–3 days for suspension, and 0–7 days for fibers.

μg/mL for vaginal lavage and plasma.

hr•μg/mL for vaginal lavage and plasma.