Skip to main content
. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Clin Sci (Lond). 2016 Oct 1;130(20):1807–1822. doi: 10.1042/CS20160397

Table 2.

Cognitive deficits in diabetic animal models in the presence or absence of VCI.

Diabetes Diabetic Model VCI Model Cognitive Impairment Ref.
Type 1 STZ ---

  • Impaired spatial memory

  • Reduced LTP

  • Enhanced LDP

  • Impaired working memory

  • Reduced memory retention

  • Amygdala-based cognitive dysfunction

 (91,92,95–97,99–101,103, 104)
NOD ---

  • Impaired spatial memory

 (91,92)
Type 2 GK rats ---

  • Impaired spatial memory

  • Impaired recognition memory

 (110,184)
Zucker rats ---

  • Impaired spatial memory

 (105)
db/db mice ---

  • Impaired spatial memory

  • Reduced LTP

  • Impaired recognition memory

  • Impaired episodic memory

 (93,105, 106)
BCAS

  • No cognition data

 (127)
HFD+STZ ---

  • Impaired spatial memory

  • Impaired recognition memory

 (108,111–113)
OLETF rats BCCAO

  • Impaired spatial memory

 (129)