Table 1.
Patient Demographics. NF- non-failing control. SV- single ventricle patients. M- male. F- female. Inotropes included dopamine and norepinephrine. PDE- phosphodiesterase. ACEI- Angiotensin converting enzyme inhibitor. BB- beta-blocker (the non-selective beta-blocker labetalol was used in NF1). PGE-prostaglandin E1, used to maintain ductus arteriosus patency. PDA- patent ductus arteriosus.
| Study ID | Age (years) | Sex | HDAC Activity | HDAC Westerns | Inotrope | Digoxin | ACEI | BB | Diuretic | Palliation History/Indication for transplant |
|---|---|---|---|---|---|---|---|---|---|---|
| NF1 | 13 | M | X | X | Y | N | N | Y | N | NA |
| NF2 | 8 | F | X | X | N | N | N | N | N | NA |
| NF3 | 7 | M | X | X | N | N | N | N | N | NA |
| NF4 | 1.4 | M | X | X | N | N | N | N | N | NA |
| NF5 | 12 | M | X | X | N | N | N | N | N | NA |
| NF6 | 14 | M | X | X | NA | NA | NA | NA | NA | NA |
| SV1 | 0.1 | F | X | X | N | N | N | N | Y | No palliation, on PGE/Primary transplant, RVH dilation |
| SV2 | 0.1 | M | X | X | N | N | N | N | Y | Aortic valvuloplasty and atrial septal stent on PGE/Not a candidate for additional surgical palliation, ventilator dependent |
| SV3 | 0.2 | M | X | X | N | N | Y | N | Y | PDA stent/Primary transplant, RV dilation |
| SV4 | 0.2 | M | X | X | N | N | N | N | Y | PDA stent/Primary transplant, RVH |
| SV5 | 0.2 | M | X | NA | NA | NA | NA | NA | No palliation, on PGE/Primary transplant, RVH | |
| SV6 | 0.1 | M | X | X | N | Y | Y | N | Y | No palliation, on PGE/Primary transplant, RVH and RV dilation |