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. 2017 Jul 20;390(10):1047–1059. doi: 10.1007/s00210-017-1406-z

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© The Author(s) 2017

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — Schematic representations of the proposed pharmacokinetic models of PTX (a) and (±)-LSF (b) following intravenous administration of each compound to rats; C_PTX and C_LSF, plasma concentrations of PTX and (±)-LSF; V_PTX and V_LSF, volumes of PTX and (±)-LSF compartments, respectively; V_PTXm and V_LSFm, volumes of PTX and (±)-LSF metabolite compartments, respectively; k_m12, first-order conversion rate constant of parent compound into metabolite; k_m21, first-order conversion rate constant of metabolite into parent compound; k_e, first-order rate constant for disappearance of parent compound; f_m, fraction of parent compound metabolized; k_em, first-order elimination rate constant of metabolite; V_max, maximal elimination rate constant; K_m, drug concentration at which the elimination rate is half-maximal