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Pharmacokinetic profile of digoxin. Data are mean (+SD) plasma digoxin concentrations versus time following a single 0.25-mg dose of digoxin administered alone (solid line, circles) and with 10 mg (a) or 25 mg (b) OCA (dotted line, x). Main figures display digoxin plasma concentration on a linear scale, and insets display log scale. Includes patients from digoxin evaluable PK population (N = 48)
