Table 1.

Steps in the computer program “Flaviclass”

Step	Action
1	Quality control, quantitative vs reference sera; checking timing of sera
2	Summing DENV 1–4 type reactions to “DENVx,” subtraction of antigen-specific cutoffs
3	Calculation of avidity indices
4	Calculation of coincidence factors
5	Estimation of cross-reactivity, based on x factors and avidity
6	Calculation of final score, per flavivirus, per serum
7	Detection of more than twofold reactivity change in serial samples
8	Judgement of patient; primary or previous infection