Table 2.
Hypoxia‐related differential gene expression in the CB compared to the SCG of adult mice by microarray analysis*
| Gene symbol | Description | Fold change (linear) | pFDR |
|---|---|---|---|
| Phd/Hif pathway and targets | |||
| Epas1(Hif2a) | endothelial PAS domain protein 1 | 102.0 | 2.49E‐03 |
| Arnt2 | aryl hydrocarbon receptor nuclear translocator 2 | 2.9 | 1.47E‐02 |
| Egln3(Phd3) | egl‐9 family hypoxia‐inducible factor 3 | −4.1 | 1.89E‐02 |
| Vegfa | vascular endothelial growth factor A | 4.2 | 1.86E‐02 |
| Vegfc | vascular endothelial growth factor C | 3.9 | 7.34E‐03 |
| Mitochondria | |||
| Ndufa4l2 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4‐like 2 | 720.9 | 3.90E‐04 |
| Ndufa8 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8 | −2.1 | 4.01E‐02 |
| Ndufa9 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9 | −3.4 | 5.17E‐03 |
| Ndufa10 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10 | −2.4 | 1.28E‐02 |
| Ndufaf7 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex assembly factor 7 | −3.1 | 1.20E‐02 |
| Ndufb6 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6 | −2.1 | 3.16E‐02 |
| Ndufs8 | NADH dehydrogenase (ubiquinone) Fe‐S protein 8 | −3.9 | 1.09E‐02 |
| Sdhd | succinate dehydrogenase complex, subunit D, integral membrane protein | ‐4.0 | 1.03E‐02 |
| Uqcrc1 | ubiquinol‐cytochrome c reductase core protein 1 | −2.6 | 1.07E‐02 |
| Cyb561 | cytochrome b‐561 | −5.0 | 2.78E‐02 |
| Cyb561d2 | cytochrome b‐561 domain containing 2 | −2.7 | 3.33E‐03 |
| Cyb5b | cytochrome b5 type B | −5.0 | 6.07E‐03 |
| Cyb5d1 | cytochrome b5 domain containing 1 | −3.6 | 3.94E‐02 |
| Cyba | cytochrome b‐245, alpha polypeptide | 3.2 | 1.49E‐02 |
| Cox4i2 | cytochrome c oxidase subunit IV isoform 2 | 10.1 | 6.03E‐03 |
| Cox8b | cytochrome c oxidase subunit VIIIb | 11.8 | 1.30E‐02 |
| Cox5a | cytochrome c oxidase subunit Va | −2.2 | 4.54E‐02 |
| Coa3 | cytochrome C oxidase assembly factor 3 | −3.0 | 2.21E‐02 |
| Cox15 | cytochrome c oxidase assembly protein 15 | −3.6 | 1.79E‐02 |
| Slc25a27 | solute carrier family 25, member 27 | −2.8 | 2.33E‐03 |
| TCA cycle/anaplerosis/biotin‐related | |||
| Pcx | pyruvate carboxylase | 4.9 | 1.31E‐02 |
| Pdha1 | pyruvate dehydrogenase E1 alpha 1 | −2.5 | 1.90E‐02 |
| Pdk4 | pyruvate dehydrogenase kinase, isoenzyme 4 | 9.1 | 3.90E‐03 |
| Clybl | citrate lyase beta like | −2.7 | 9.23E‐03 |
| Acacb | acetyl‐Coenzyme A carboxylase beta | 2.7 | 9.57E‐03 |
| Slc7a5 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 | −3.6 | 2.24E‐02 |
| Idh1 | isocitrate dehydrogenase 1 (NADP+), soluble | −3.5 | 1.34E‐02 |
| Idh3a | isocitrate dehydrogenase 3 (NAD+) alpha | −3.1 | 5.50E‐03 |
| Idh3b | isocitrate dehydrogenase 3 (NAD+) beta | −4.6 | 3.83E‐02 |
| Ogdhl | oxoglutarate dehydrogenase‐like | −2.6 | 2.09E‐02 |
| Ogfod1 | 2‐oxoglutarate and iron‐dependent oxygenase domain containing 1 | −3.2 | 9.12E‐03 |
| Mdh1 | malate dehydrogenase 1, NAD (soluble) | −2.4 | 8.89E‐03 |
| Others | |||
| Gdnf | glial cell line derived neurotrophic factor | 2.1 | 9.36E‐03 |
| Pparg | peroxisome proliferator activated receptor gamma | 2.4 | 8.63E‐03 |
*pFDR (P value adjusted with the false discovery rate) < 0.05 and fold change >2 or <−2.