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. 2017 Sep 14;7:11551. doi: 10.1038/s41598-017-10443-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Gene expression profiling of T98G cells upon treatment of FAEW or fluoxetine. (A and B) Pathway analyses: Top cellular pathways affected by FAEW and fluoxetine examined by mRNA microarray hybridization. (A) Shows the comparison between FAEW and fluoxetine. (B) Shows the comparison between H₂O₂, H₂O₂ and FAEW, H₂O₂ and fluoxetine. P-values were calculated using right-tailed Fisher’s exact test. (C) Deregulated genes under the influence of the common upstream regulator NFE2L2 (NRF2) inhibited by FAEW (left) and fluoxetine (right).