Table 1.
Most pronounced upstream transcription factors for deregulated genes upon different treatments.
| Comparison with control | Comparison with H2O2 | |||||
|---|---|---|---|---|---|---|
| FAEW | Fluoxetine | H2O2 | H2O2 + FAEW | H2O2 + Fluoxetine | H2O2 + FAEW | H2O2 + Fluoxetine |
| RBPJ | SOX2 | KDM5B | NUPR1 | TP53 | JUN | NFE2L2 |
| HMGA1 | EGR2 | TP53 | KDM5B | FOXO1 | RELA | PDX1 |
| HLX | ATF4 | NFE2L2 | RELA | TCF7L2 | FOXO1 | TCF3 |
| CEBPD | TCF3 | FOXM1 | JUN | NEUROG1 | CREB1 | HMGA1 |
| NFE2L2 | GFI1 | MYC | CREB1 | TFEB | DDIT3 | MED1 |
| CTNNB1 | SPI1 | TBX2 | NFE2L2 | IRF4 | NUPR1 | MYC |
| CEBPA | SMAD4 | CCND1 | REL | RELA | ECSIT | FOXM1 |
| SOX2 | HIF1A | TAL1 | PPRC1 | SRF | JUNB | ERG |
| EGR1 | GATA1 | ATF4 | RELB | CREBBP | REL | ATF6 |
| RELB | SMARCB1 | ATF6 | TP53 | SP1 | NFE2L2 | RUNX2 |
| JUNB | E2F3 | REL | ECSIT | XBP1 | STAT3 | NUPR1 |
| EBF1 | JUN | MED1 | SPI1 | NUPR1 | ATF2 | FOS |
| NKX2-3 | MTPN | MITF | WT1 | NFKBIA | SOX2 | BRCA1 |
| YY1 | MDM2 | NUPR1 | ATF4 | NFE2L2 | FOXL2 | SMARCE1 |
| MITF | RUNX2 | CEBPB | TP63 | NOTCH1 | CEBPB | STAT5B |
| ETS2 | KLF4 | XBP1 | RUNX1 | CREB1 | RBPJ | SREBF1 |
| GLI1 | NKX2-3 | BRCA1 | NCOA3 | VDR | FOXO3 | CTNNB1 |
| SRF | IRF3 | SRF | TBX2 | MEF2C | HIF1A | TFEB |
| STAT3 | HIC1 | E2F1 | YY1 | CTNNB1 | TP53 | SOX2 |
| SPDEF | TFEB | GPS2 | FLI1 | BRCA1 | CREBBP | TP63 |
| CCND1 | MYC | IFI16 | CARM1 | JUN | NFKB1 | NKX2-3 |
| EP300 | HMGA1 | FOXO1 | TFAP2C | HOXA10 | RB1 | SIRT1 |
| TCF7L2 | STAT1 | FOS | MEF2D | TAL1 | EP300 | FOXO4 |
| HDAC6 | RB1 | IRF3 | POU2F1 | FOS | NKX2-3 | TP73 |
| DACH1 | E2F1 | STAT3 | GATA3 | HIC1 | EZH2 | NFKBIA |
| FOSL1 | NRF1 | RB1 | IRF6 | ELK1 | USF1 | DDIT3 |
| TP53 | BRCA1 | CREB1 | ATF2 | IKZF1 | CDKN2A | FOXO3 |
| SMARCA4 | TP63 | HIF1A | CTNNB1 | IFI16 | CEBPA | HIF1A |
| BRCA1 | ETS2 | HIC1 | FOXL2 | FOXO3 | TP73 | CREB1 |
| CITED2 | NFE2L2 | EGR1 | MITF | GLI1 | SIRT1 | GLI1 |