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. 2017 Sep 14;7:11551. doi: 10.1038/s41598-017-10443-6

Table 2.

Target genes in the corresponding dataset regulated by NRF2.

Comparison Treatment Activation z-score P-value of overlap Target molecules in dataset
Compared with control FAEW 1.790 1.49E-02 CXCL8, GCLM, HMOX1, GPX1, IL6, SAT1, SCG2, COL1A1
Fluoxetine 1.000 3.64E-04 ATF4, BRCA1, DDX50, DHCR7, ERP29, HMOX1, LGALS8, MAFG, MGST3, NOCT, NQO1, PSMD12, SNAI2, TXNRD1
H2O2 2.390 7.08E-02 ATF4, CXCL8, HMOX1, PSAT1, RRS1, VCAM1
H2O2 + FAEW 2.674 3.04E-03 AHR, ATF4, BNIP3, CREG1, CXCL8, GCLM, GPX1, HMOX1, IL6, MAFF, MGST1, NQO1, PAFAH1B1, RRS1, S100P, SLC6A9, SLC7A11, SOD2, TXNRD1, VCAM1
H2O2 + Fluoxetine 1.685 2.58E-04 ALDH3A1, CREG1, DAD1, GCLM, HERPUD1, IL6, MGST1, MGST3, SCG2, SRXN1, HMOX1
Compared with H2O2 H2O2 + FAEW 1.837 4.25E-03 CXCL8, HMOX1, IL6, MAFF, SOD2
H2O2 + Fluoxetine 2.250 8.91E-02 CTSD, DDIT3, DHCR7, GCLM, IL6, SRXN1