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. 2017 Sep 14;7:11593. doi: 10.1038/s41598-017-11773-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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RAGE expression and its inhibition by sRAGE through MAPK pathway. (A,B) Relative levels of RAGE (green) were determined by immunohistochemistry analysis. The levels of RAGE in L6 cells after AGE-albumin (AA), AA with sRAGE treatment (AA/sRAGE) and in PIRI-CLI (IR) without or with sRAGE treatment. (C,D) Apoptotic L6 cells (red) and skeletal muscles of PIRI-CLI mice (red) with skeletal muscle cell marker (α-actinin, green) were analyzed by TUNEL labeling. (E,F) Level of MAPK intensity was determined in mice muscle by immunohistochemistry and Immunoblotting. Scale bar = 50 μm. mean ± s.d. (*P < 0.05) and (^†P < 0.01).