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. 2017 Sep 14;7:11549. doi: 10.1038/s41598-017-10720-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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HA/TCP mediated moderate new bone formation in mandibular bone defects. (A) Two months after surgery, the control group treated with HA/TCP alone showed moderate amounts of new bone in the defects. HA/TCP was also detected in the mineralized tissues (dark blue lines show the margins of the bone defect made in surgery). (B) Higher magnification of the area enclosed in a green rectangle in (A) shows newly formed bone was detected around HA/TCP particles. There were abundant blood vessels in the newly formed bone. (C) Control HA/TCP specimens show large volumes of HA/TCP particles remaining in the bone defect area, around connective tissues (purple arrows; the area enclosed with a blue rectangle in (A). HA = HA/TCP particles, NB = new bone, CT = connective tissue, BV = blood vessel. Scale bar = 200 µm in (A) and Scale bar = 50 µm in (B,C).