Table 2.
Eight high-order DNME models.
| Algorithm | metrics | DNME-1 | DNME-2 | DNME-3 | DNME-4 | DNME-5 | DNME-6 | DNME-7 | DNME-8 |
|---|---|---|---|---|---|---|---|---|---|
| NHSA-DHSC | 1st Power | 100% | 100% | 100% | 100% | 100% | 100% | 2% | 100% |
| 2nd Power | 100% | 100% | 100% | 100% | 100% | 100% | 2% | 100% | |
| TPR | 100% | 100% | 100% | 100% | 100% | 100% | 2% | 100% | |
| SPC | 100% | 100% | 100% | 90% | 100% | 100% | 98% | 100% | |
| ACC | 100% | 100% | 100% | 95% | 100% | 100% | 50% | 100% | |
| FDR | 0% | 0% | 0% | 9% | 0% | 0% | 50% | 0% | |
| MEs | 1093 | 1081 | 2342 | 4415 | 2175 | 3870 | 50001 | 3849 | |
| Runtime | 1.48 | 1.44 | 4.1 | 7.67 | 3.87 | 7.61 | 102.41 | 9.38 | |
| BEAM | Runtime | 5.75 | 5.62 | 5.88 | 5.7 | 5.76 | 5.74 | 5.75 | 5.73 |
| Power | 38% | 6% | 0% | 0% | 0% | 0% | 0% | 0% | |
| TPR | 38% | 6% | 0% | 0% | 0% | 0% | 0% | 0% | |
| SPC | 100% | 100% | 100% | 100% | 100% | 100% | 100% | 100% | |
| PPV | 100% | 100% | 100% | 100% | 100% | 100% | 100% | 100% | |
| ACC | 59% | 46% | 30% | 44% | 43% | 44% | 45% | 43% | |
| FDR | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | |
| SNPHarvester | Power | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% |
| Runtime | 7.64 | 7.55 | 12.94 | 13.62 | 13.47 | 17.67 | 17.91 | 17.47 | |
| TPR | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | |
| SPC | 100% | 100% | 98% | 100% | 85% | 100% | 100% | 100% | |
| ACC | 50% | 50% | 50% | 50% | 46% | 50% | 50% | 50% | |
| FDR | 0% | 0% | 100% | 0% | 100% | 0% | 0% | 0% | |
| CSE | Power | 53% | 52% | 9% | 8% | 8% | 3% | 1% | 1% |
| MEs | 49856 | 49855 | 49795 | 49788 | 49791 | 49712 | 49718 | 49709 | |
| Runtime | 71.89 | 66.63 | 110.92 | 110.06 | 110.51 | 252 | 238.62 | 275.23 | |
| TPR | 53% | 52% | 9% | 8% | 8% | 3% | 1% | 1% | |
| SPC | 53% | 52% | 9% | 8% | 8% | 3% | 1% | 1% | |
| ACC | 53% | 52% | 9% | 8% | 8% | 3% | 1% | 1% | |
| FDR | 47% | 48% | 91% | 92% | 92% | 97% | 99% | 99% |