Table 2.
Comparison of concentrations of 16 cytokines between both study groups.
| Cytokine | Concentration in CGF (log2 pg/ml) Median (IQR) | P Value | |
|---|---|---|---|
| Control group | Perio group | ||
| GMCSF | 7.244 (1.214) | 7.954 (1.485) | <0.001 |
| IL1alpha | 14.931 (0.889) | 17.183 (1.665) | <0.001 |
| IL1beta | 11.500 (0.996) | 14.132 (1.357) | <0.001 |
| IL6 | 7.285 (1.956) | 8.296 (2.002) | <0.001 |
| IL12p40 | 3.120 (0.970) | 4.173 (0.927) | <0.001 |
| IL17A | 3.006 (2.029) | 4.867 (1.277) | <0.001 |
| IL17F | 2.046 (1.525) | 3.373 (1.710) | <0.001 |
| TNFalpha | 2.862 (1.697) | 4.554 (0.979) | <0.001 |
| IFNgamma | 2.417 (1.185) | 3.363 (1.395) | 0.001 |
| IL2 | 3.424 (1.133) | 3.973 (0.702) | <0.001 |
| IL3 | 5.607 (1.071) | 6.649 (1.880) | <0.001 |
| IL4 | 2.745 (2.449) | 3.713 (2.584) | <0.001 |
| IL5 | 3.219 (1.301) | 3.625 (0.836) | 0.495 |
| IL10 | 2.640 (1.577) | 3.101 (2.080) | 0.087 |
| IL12p70 | 3.174 (3.053) | 3.864 (1.976) | 0.352 |
| IL13 | 4.904 (2.881) | 5.066 (3.514) | 0.458 |
IQR, interquartile range; CGF, crevicular gingival fluid. Concentration range for each biomarker analysed: GMCSF, 0.53–55,050 pg/ml; IFNgamma, 0.02–6,650 pg/ml; IL1alpha, 0.34–28,800 pg/ml; IL1beta, 0.09–23,150 pg/ml; IL2, 0.04–13,700 pg/ml; IL3, 0.19–26,500 pg/ml; IL4, 0.10–29,250 pg/ml; IL5, 0.04–17,800 pg/ml; IL6, 0.10–27,200 pg/ml; IL10, 0.04–10,050 pg/ml; IL12p40, 0.14–27,350 pg/ml; IL12p70, 0.26–18,050 pg/ml; IL13, 0.34–23,700 pg/ml; IL17A, 0.36–30,900 pg/ml; IL17F, 0.25–34,700 pg/ml; TNFalpha, 0.21–16,800 pg/ml.