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. 2017 Sep 14;7:11569. doi: 10.1038/s41598-017-11885-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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TGF-β1 induces the expression of miR-503 in glioblastoma cells. (A) Correlation analysis of miR-503 level and miR-424 level in the NCI 60 cancer cell panel using Pearson correlation (R² = 0.7421). (B) Quantitative PCR analysis of miR-503 expression in U251, A172, LN-229 and T98G cells treated with TGF-β1 at different doses for 48 h. (C) Quantitative PCR analysis of miR-503 expression in U251, A172, LN-229 and T98G cells treated with 8ng/ml TGF-β1 at different time points. (D) Western blot analysis showing the phosphorylation of Smad2/3 in U251, A172,LN-229 and T98G cells treated with TGF-β1 at different doses for 30 min. (E) Quantitative PCR analysis of miR-503 expression in U251, A172, LN-229 and T98G cells treated with TGF-β1 alone or with SB-431542 or K02288 for 48 h.