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. 2017 Sep 14;8:539. doi: 10.1038/s41467-017-00607-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — DREAM DNA methylation analysis of whole blood DNA from different species. a Unsupervised hierarchical clustering analysis of CpG sites in CpG island (CGI), non-CGI, and all genomic regions. The green to red color scale indicates the methylation percentage. The color codes for age are shown on the left. b DNA methylation in old vs. newborn/infant/young. Average DNA methylation level of each CpG site in old individuals (y axis) is plotted against that in newborn/infant/young individuals (x axis). The red and green dots represent CGI and non-CGI CpG sites, respectively. The low range (0–20%) and high range (80–100%) of methylation status are shown. c Volcano plots show CpG sites differentially methylated between old and newborn/infant/young. Plots on left are sites in promoter CGI (red) and on right site are sites in non-promoter non-CGI (green). The promoter region is defined as –1 kb ≤ TSS ≤+ 500 bp. The methylation difference between old and newborn/infant/young is shown on the x axis, the p-value (in –log10 scale) on the y axis. The horizontal line indicates p-value at 0.05