Fig. 2.
Methylation analysis by DREAM in mouse, monkey, and human DNA. Area-proportional Venn diagrams of overlapping gene promoters (−1kb < TSS <+ 500 bp) showing age-related methylation drift in whole blood in each combination. The denominators represent the number of homologous genes with high-quality sequence data (sequencing depth ≥ 100 reads in 75% of cases), which are detectable between two species in each comparison. We counted the number of genes using human homolog gene names of mouse and monkey genes in each comparison. A χ 2-test using 2×2 tables (Supplementary Table 12) was used to calculate p-values for the significance of the overlaps. p-values are indicated on the right side