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. 2017 Sep 14;8:539. doi: 10.1038/s41467-017-00607-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Cross-species comparison of aging drift. a The association between age (x axis) and methylation percentage of 10 hypermethylated ARM genes (y axis) homologous in each species. Dots represent methylation values at 10 genes in each individual (mouse; young, n = 6, middle, n = 13, old, n = 12, monkey; infant, n = 12, middle, n = 15, old, n = 12, human; newborn, n = 13, young, n = 54, middle, n = 27, old, n = 45). p-values of the linear regression slope were calculated by t-test (two-tailed). b The association between methylation drift rate and lifespan. The x axis represents maximum longevity of each species (mouse; 4 years, monkey; 40 years, human; 122.5 years), and the y axis represents methylation changes per year. The scales are logarithmic. The maximum longevities of the three species were obtained from The Animal Ageing and Longevity Database (http://genomics.senescence.info/species/). The R-squared values and their p-values (F-test, two-tailed) were calculated