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. 2017 Sep 14;7:11609. doi: 10.1038/s41598-017-11944-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Olanzapine (Oz) and haloperidol (Hp) differentially modify burst structure in excitatory and inhibitory units. The activity line plots and quantifications are shown for 21 days in in vitro cultures. (a–c) The representative bursts are shown for putative excitatory and inhibitory units in control, olanzapine, and haloperidol conditions, respectively. (a’–c’) The bursts in the same units as in (a–c) are shown after 30 minutes of 6 µM bicuculline methiodide application. Vertical bar, 15 mV; horizontal bar, 100 ms. (d–f) The quantification of key burst structure parameters is shown for putative excitatory units (minimum 115 electrodes, N = 4) and inhibitory units (minimum 32 electrodes, N = 4): number of spikes in a burst (SpiB) (d) mean intraburst spiking frequency (MIF) (e) and burst duration (Bdur) (f). (d’–f’) Burst structure parameters are quantified after 30 minutes of 6 µM bicuculline methiodide application, same units as in (d–f). The asterisks indicate significant differences with the control, based on the Kruskal-Wallis ANOVA test (*p < 0.05; **p < 0.01; ***p < 0.001).