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. 2017 Sep 14;7:11619. doi: 10.1038/s41598-017-11830-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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sPLA₂-IIA induced proliferation affects various epidermal compartments. (a) Immunofluorescence staining of Ki67 to assess cell proliferation in intact epidermal sheet of tail skin by wholemount assay at PD21. (b) Immunofluorescence labelling of Lrig1 in WT and K14-sPLA₂-IIA homozygous mice skin sections at PD41. Dashed lines represent the boundary of junctional zone area. (c) Immunofluorescence staining of loricrin as a differentiation marker to label the cells of granular layers in WT and K14-sPLA₂-IIA homozygous mice at PD49.