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. 2017 Sep 14;7:11619. doi: 10.1038/s41598-017-11830-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Proposed model of impaired hair follicle cycling in K14-sPLA₂-IIA homozygous mice. WT- Graphical representation of hair follicle cycling in wild type mice from hair follicle morphogenesis to second telogen at PD49, which represented by presence of club hair and subsequent progression to the next hair cycle. Homozygous- Graphical representation of hair follicle cycling in K14-sPLA₂-IIA homozygous mice represented by abnormal morphology of hair follicle with presence of affected hair shaft. (WT-Wild type Homo- K14-sPLA₂-IIA homozygous IFE: inter follicular epidermis, SG: sebaceous gland, DP: dermal papilla, PD-Postnatal days).