Table 1.
Blood pressure, mechanical properties and composition of the carotid artery
| CT | Synm−/− | Vim−/− | Vim−/−Synm−/− | |
|---|---|---|---|---|
| Number | 7 | 6 | 6 | 4 |
| Conscious mice | ||||
| SAP (mmHg) | 109 ± 4 | 107 ± 4 | 91 ± 4* | 99 ± 4 |
| Anesthetized mice | ||||
| SAP (mmHg) | 113 ± 5 | 109 ± 5 | 91 ± 2* | 100 ± 4 |
| DAP (mmHg) | 79 ± 4 | 75 ± 5 | 62 ± 2* | 66 ± 4 |
| MAP (mmHg) | 91 ± 4 | 87 ± 5 | 72 ± 1* | 77 ± 4 |
| PP (mmHg) | 34 ± 3 | 34 ± 3 | 29 ± 3 | 34 ± 3 |
| HR (beats/min) | 438 ± 14 | 446 ± 18 | 397 ± 19 | 401 ± 17 |
| Parameters within common range | ||||
| MDia80–88 (µm) | 510 ± 32 | 531 ± 34 | 531 ± 20 | 522 ± 49 |
| MDist80–88 (10−3 mmHg−1) | 13.5 ± 1.9 | 12.4 ± 2.0 | 6.3 ± 0.3*§ | 6.9 ± 1.2*§ |
| MWS400–800 (kPa) | 250 ± 22 | 245 ± 18 | 194 ± 5*§ | 174 ± 12*§ |
| Histology of the CA | ||||
| MCSA (mm2 10−3) | 25 ± 2 | 27 ± 1 | 24 ± 2 | 31 ± 1* |
Values are means ± SEM; CT, control mice; DAP, diastolic arterial pressure; MAP, mean arterial pressure; PP, pulse pressure; MDia, mean diameter; MDist, mean distensibility; MWS, mean wall stress. *P < 0.05 versus CT §P < 0.05 versus Synm−/−.