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. 2017 Sep 14;7:11527. doi: 10.1038/s41598-017-10078-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Profile of MMP production in 2D and 3D condition in three cell lines. Zymogram analysis is done using spent medium, cell lysate and cell pellet of two conditions (2D and 3D) of three cell lines. Collagenase is used as positive control. Bands were identified by mol wt.