Table 3.

ROC analysis of serum biomarkers individually and combined for GC detection

Models		AUC(95%CI)	P -value
Single-model	PGI	0.549(0.506–0.595)
	PGII	0.641(0.596–0.682)
	PGI/II	0.735(0.696–0.773)
	HpAb	0.736(0.700–0.775)
	OPN	0.715(0.675–0.752)
Dual-model	PGI/II-OPN	0.787(0.752–0.822)	<0.001a, <0.001b
	PGI/II-HpAb	0.786(0.751–0.820)	<0.001a, <0.001c
	OPN- HpAb	0.801(0.768–0.834)	<0.001b, <0.001c
Tri-model	PGI/II-HpAb-OPN	0.826(0.795–0.858)	<0.001d, <0.001e,0.006f
	Lauren classification
	intestinal	0.827(0.796–0.858)	0.219g
	diffuse	0.826(0.795–0.858)
	Tumor stage
	early	0.821(0.789–0.852)	0.469h
	late	0.816(0.784–0.848)

^aCompared with the AUC of PGI/II.

^bCompared with the AUC of OPN.

^cCompared with the AUC of HpAb.

^dCompared with the AUC of PGI/II-OPN.

^eCompared with the AUC of PGI/II-HpAb.

^fCompared with the AUC of OPN- HpAb.

^gCompared with the AUC between Lauren classification.

^hCompared with the AUC between stage.