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. 2017 Sep 14;7:11603. doi: 10.1038/s41598-017-11596-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Claudin-11 immunoreactivity in a 7 wpc embryo and a 10 wpc fetus. (A) 7 wpc embryo: the arachnoid barrier cell layer appears initially covering the inner surface of the tentorium cerebelli (TC); it is most prominent in the medial part where the ‘blades’ of the tentorium meet (insert). Note that there is no indication of a claudin-11 positive arachnoid layer covering the forebrain (A). The choroid plexus (CHP) of the 4^th ventricle (4 V), positively immunostained for claudin-11, is starting to differentiate, and the sinuses are already present. (B) 10 wpc fetus: the basal forebrain shows a strongly claudin-11 immunopositive arachnoid barrier cell layer (four basolateral arrowheads) creating a well-defined subarachnoidal space in contrast to the dorso-medial forebrain where the claudin-11 immunopositive arachnoid membrane fades out along the surface (three upper lateral arrowheads). Abbreviations: CHP: choroid plexus; 4 V: fourth ventricle; LV: lateral ventricle; OV: otic vesicle; PG: pineal gland; RL: rhombic lip; 3 V: third ventricle; SS: sigmoid sinus; ST: transverse sinus; TC: tentorium cerebelli; WPC: weeks post conception; cld: claudin. (A,B) Same magnification. Scale bar: 1000 μm.