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Amount of ITR was found in the receiver compartment (μg/cm2) and hoof membrane (μg/mg) after in vitro transport studies.
| Amount of ITR | ||||
|---|---|---|---|---|
|
| ||||
| Mode of drug loading | In vitro studies | |||
|
| ||||
| 24 h study | 3 days (8 h/day) study | |||
|
|
|
|||
| Receiver compartment (μg/cm2) | Hoof membrane (μg/mg) | Receiver compartment (μg/cm2) | Hoof membrane (μg/mg) | |
| Passive | 0.03 ± 0.01 | 0.95 ± 0.54 | 0.08 ± 0.01 | 1.3 ± 0.60 |
| Iontophoresis | 0.91 ± 0.11 | 4.8 ± 1.2 | 2.12 ± 0.30 | 4.95 ± 1.52 |
