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Amount of drug was found in the nail bed (μg/mg) and nail plate (μg/mg) after ex vivo transport studies.
| Amount of ITR | ||||
|---|---|---|---|---|
|
| ||||
| Mode of drug loading | Ex vivo studies | |||
|
| ||||
| 24 h study | 3 days (8 h/day) study | |||
|
|
|
|||
| Nail bed (μg/mg) | Nail plate (μg/mg) | Nail bed (μg/mg) | Nail plate (μg/mg) | |
| Passive | 0.003 ± 0.09 | 1.61 ± 0.73 | 0.11 ± 0.07 | 1.75 ± 0.98 |
| Iontophoresis | 1.17 ± 0.60 | 4.64 ± 1.14 | 2.65 ± 1.09 | 4.96 ± 1.64 |
