TABLE 3.
Results of bioassays of brain material from selected pigs in Tg002 mice that express porcine prion protein
| Donor animal no. | Donor treatment group (donor incubation period [mpi]) | Tg002 mouse |
|
|---|---|---|---|
| Attack ratea | Mean incubation period (dpi) | ||
| 18 | i.c. inoculated market wt (6) | 2/29 | 244 |
| 27 | i.c. inoculated aged (64) | 3/29 | 167 |
| 28 | i.c. inoculated aged (73) | 2/27 | 314, 701b |
| 32 | Orally inoculated market wt (6) | 0/28 | >700 |
| 48 | Orally inoculated aged (72) | 14/28 | 263 |
a
PrPSc in the brains of mice was detected by an antigen capture EIA.
b
The survival times of these two mice are so disparate that calculation of a mean incubation period would not be meaningful.