TABLE 1.

Known and putative N-linked glycans in DPP4 orthologs^a

Ortholog	Residue
hDPP4		85	92	150		219	229			281	321						520
bDPP4		82	89	147		216	226	272			315		332	393	432	490
mDPP4		83	90	144			223				315	328					514
fDPP4		84	91		178		228			280	320				437		519
haDPP4		83	90	148			227		275		319	332					518
gpDPP4	32	295	302	360			439			491	531		548				730

^aNumbers indicate the residues known (hDPP4) or predicted (all other DPP4 orthologs) (33) to have N-linked glycans for each DPP4 molecule. All residues are numbered relative to the given DPP4 molecule, with columns representing residues that align. Among the eight N-linked glycans in hDPP4, only four are conserved across all orthologs. Bold font indicates sites that align to within two residues of a contact residue in hDPP4 (see reference 29).