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Replication of wild-type versus M D62A and M D62A E181A mutant viruses. Viral titers from media harvested from cells infected at the indicated time points at an MOI of 0.1 (A) or 1.0 (B) are shown. Error bars reflect SEM. *, P < 0.05; **, P < 0.01; ***, P < 0.001 for mutant virus results in a comparison with the rWT virus results at the same time point.
