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The EBNA1 DBD forms an obligate dimer that packs as a hexamer (trimer of dimers). The trimer interface (indicated in red) is critical for episome maintenance. The hexameric assembly binds DNA on the same surface above each hexameric wheel and can bind between wheels through PGP loop interactions (not modeled). One EBNA1 dimer occupies a single 30-bp FR element, and the hexamer is predicted to include 90 bp (3 FR repeat elements).
