FIG 3.
TCR repertoire bias for Tax301-309-CTLs in ACs and ATL patients analyzed at the single-cell level. Individual Tax-tetramer-positive cells or clones detected in sACs (n = 7,782 cells and 56 clones), hrACs (n = 3,325 cells and 28 clones), and ATL patients (n = 4,351 cells and 56 clones) were analyzed with respect to the usage frequencies of TCR-β genes. The usage frequency for a given BV gene family or BJ genes is described in Results. (a and b) TCR-BV repertoires (a) and TCR-BJ repertoires (b) in Tax301-309-CTLs at the cellular and clonal levels. (c) TCR-BJ repertoires of 35 PDR motif-expressing BV7-9+Tax301-309-CTL clones from ACs and ATL patients. Black and gray bars represent TCR-BJ genes with usage frequencies above and below the mean values + 2 SDs, respectively.