FIG 2.

Neutralizing activity of MAbs CH42 and CH43 in B78H1-A10 mouse cells that express human HVEM (hHVEM) (but not nectin-1), B78H1-C10 mouse cells that express human nectin-1 (but not HVEM), Vero cells that express endogenous simian HVEM and nectin-1, and primary HFF. Stock concentrations of MAbs and human IVIG were 1 mg/ml and 10 mg/ml, respectively. Fifty percent HSV-neutralizing titers plotted as the reciprocal of the dilution are shown for HSV-1 McKrae and HSV-2 333 in the presence of MAbs CH42, CH43, and A32 (human IgG1 isotype control) or IVIG, a positive control. Similar results were obtained in two experiments, and a representative result is shown.