HSV-1 shedding from eyes of mice treated with MAb CH42, CH43, or isotype control (A32) and infected with HSV-1 by corneal scarification. The mice were treated and infected as described in the legend to Fig. 4. (A) Eye swabs were obtained for the first 3 days after infection, HSV-1 titers were measured in Vero cells, and daily group mean titers were determined. The error bars indicate standard deviations. (B) Correlation of the dose of MAb (0, 6, 30, 150, and 450 μg/mouse for CH42 and 0, 6, 30, and 150 μg/mouse for CH43) with the mean HSV-1 titer in eye swabs from mice during the first 3 days after infection. Each point represents the results for one mouse.